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Toxoplasma gondii: The enzymic defect of a mutant resistant to 5-fluorodeoxyuridine

โœ Scribed by E.R. Pfefferkorn

Book ID
115899494
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
901 KB
Volume
44
Category
Article
ISSN
0014-4894

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Regulation of thymidylate synthase enzym
Regulation of thymidylate synthase enzyme synthesis in 5-fluorodeoxyuridine-resistant mouse fibroblasts during the transition from the resting to growing state
โœ Chung-Her Jenh; Lakshmi G. Rao; Lee F. Johnson ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 671 KB

Thymidylate synthase (TS) activity is very low in resting mouse 3T6 fibroblasts but increases sharply in growth-stimulated cells at about the same time the cells enter S phase. To study the mechanism responsible for the increase in TS level, we isolated a 5-fluorodeoxyuridine (5-FdUrd)-resistant cel