Toxicology update: the cardiotoxicity of the oxidative stress metabolites of catecholamines (aminochromes)
✍ Scribed by George S. Behonick; Mark J. Novak; Eric W. Nealley; Steven I. Baskin
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 122 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0260-437X
- DOI
- 10.1002/jat.793
No coin nor oath required. For personal study only.
✦ Synopsis
This toxicology update reviews the oxidative stress metabolites of catecholamines, postulated to be the biochemical initiators of cardiotoxicity. A brief overview of catecholamine metabolism is provided with several noteworthy historical observations relating to the autoxidation and rearrangement of epinephrine. The basic chemical and physical properties of adrenochrome and adrenolutin are discussed. The autoxidative, enzymatic and cellular basis for the transformation of catecholamines to oxidative metabolites is reviewed. Mechanisms seeking to account for the observed cardiotoxic changes in isolated heart perfusion studies and in vivo models are described. Published in 2001 by John Wiley & Sons, Ltd.