Toxicological research on substances from fusarium nivale III.: The structure of nivalenol and its monoacetate
✍ Scribed by Takashi Tatsuno; Yasuo Fujimoto; Yuko Morita
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 208 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Numerous observations(l) of intoxication in animals fed scabby grains prompted us to isolate toxic principles from the grains infected with Fusaria. Scirpene type sesquiterpenoids, nivalenol (I): mp 222-223' and fusarenon: mp 78-80' have been obtained by Tatsuno et al(2) and Morooka et a1.(3) from rice grains polluted by Fusarium nivale Fn-2, a strain originally isolated from actually damaged wheat. In addition, civalenol monoacetate (II) possessing a marked cytotoxic activity has recently been isolated from a culture broth of the fungus by Y. Ueno. S. G. Yates et a1.(4) reported that scirpene type sesquiterpenoid (III) was obtained from Fusarium nivale which isolated from tall fescue, as well as a butenolide. Diacetoxyscirpenol (IV) and 4,15-diacetoxy-3a,7a-dihydroxyscirp-9en-a-one (V), have been isolated from the plant parasitic fungus Fusarium equiseti and from culture filtrates of E. diversisporum, 2. sambucinum and E. tricinctum by P. W. Brian et a1.(5), H. P. Sigg et a1.(6) and J. R. Bamburg et a1.(7).