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Toxicological evaluation of an immunotoxin in rats and monkeys by intravenous route

✍ Scribed by B. Remandet; D. Gouy; P. Vic; G. Mazué


Book ID
103624614
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
82 KB
Volume
7
Category
Article
ISSN
0192-0561

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A Ber-H2/saporin immunotoxin, consisting of the single-chain ribosome-inactivating protein saporin-S6 and the anti-CD30 monoclonal antibody Ber-H2, gave encouraging results in the treatment of refractory Hodgkin's disease but caused a transient hepatotoxicity. The accumulation of Ber-H2/saporin conj