Toxicological comments to the discussion about REACH (H. Greim, M. Arand, H. Autrup, H.M. Bolt, J. Bridges, E. Dybing, R. Glomot, V. Foa, R. Schulte-Hermann, Arch Toxicol 2006, 80: 121–124). Reply to the letter to the editor: the need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative, by B.J. Blaauboer and M.E. Andersen (Arch Toxicol 2007, 81: 385–387)