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Toxicological assessment of orally delivered nanoparticulate insulin

✍ Scribed by Reis, Catarina P.; Figueiredo, Isabel V.; Carvalho, Rui A.; Jones, John; Nunes, Patrícia; Soares, Ana F.; Silva, Cristina F.; Ribeiro, António J.; Veiga, Francisco J.; Damgé, Christiane; Cabrita, António M. S.; Neufeld, Ronald J.

Book ID
120319146
Publisher
Informa plc
Year
2008
Tongue
English
Weight
463 KB
Volume
2
Category
Article
ISSN
1743-5390

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Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response
✍ Catarina P. Reis; Francisco J. Veiga; António J. Ribeiro; Ronald J. Neufeld; Chr 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 446 KB

The aim of this study was to characterize and evaluate a novel oral insulin nanoparticulate system based on alginate-dextran sulfate core, complexed with a chitosan-polyethylene glycol-albumin shell. Insulin-loaded nanospheres (25, 50, 100 IU/kg) administered orally to diabetic rats reduced glycemia