Toxicologic Pathology for Non-Pathologists

✍ Scribed by Thomas J. Steinbach, Daniel J. Patrick, Mary Ellen Cosenza

• Publisher: Springer New York;Humana
• Year: 2019
• Tongue: English
• Leaves: 918
• Edition: 1st ed. 2019
• Category: Library

✦ Synopsis

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances.
Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

✦ Table of Contents

Front Matter ....Pages i-x
Introduction to Toxicologic Pathology (George A. Parker)....Pages 1-44
The Pathology Report, Peer Review, and Pathology Working Group (Ted A. Birkebak, Peter C. Mann)....Pages 45-77
Routine and Special Techniques in Toxicologic Pathology (Pamela Blackshear, Erica Carroll, Sasmita Mishra, Matthew Renninger, Arun Tatiparthi)....Pages 79-112
Pathology of the Liver and Gallbladder (Robert R. Maronpot, David E. Malarkey)....Pages 113-136
Pathology of the Gastrointestinal Tract and Exocrine Pancreas (Mark J. Hoenerhoff, Arun Kumar R. Pandiri)....Pages 137-199
Pathology of the Urinary System (Kendall S. Frazier)....Pages 201-250
Pathology of the Nervous System (Juliana S. Lee, Sarah D. Cramer, Mark T. Butt)....Pages 251-277
Pathology of the Cardiovascular System (Joshua H. Decker, Radhakrishna Sura, Paul W. Snyder)....Pages 279-309
Pathology of the Respiratory System (Jack R. Harkema, James G. Wagner)....Pages 311-354
Pathology of the Lymphoid System (Tracey L. Papenfuss, Marlon C. Rebelatto, Brad Bolon)....Pages 355-395
Pathology of the Male and Female Reproductive System and Mammary Gland (Justin D. Vidal)....Pages 397-482
Pathology of the Integumentary System (Kelly L. Diegel)....Pages 483-535
Pathology of the Endocrine System (Brent E. Walling, Thomas J. Rosol)....Pages 537-569
Pathology of Bone, Skeletal Muscle, and Tooth (Stacey L. Fossey, D. Greg Hall, Andrew W. Suttie, Martin Guillot, Aurore Varela)....Pages 571-618
Pathology of the Eye (Leandro B. C. Teixeira)....Pages 619-659
Pathology of the Ear (Kenneth A. Schafer)....Pages 661-688
Principles of Toxicologic Clinical Pathology (Adam Aulbach, Laura Cregar)....Pages 689-743
Carcinogenicity (Paul Howroyd)....Pages 745-778
Pathology of Juvenile Animals (Catherine A. Picut, Amera K. Remick)....Pages 779-849
Non-mammalian Laboratory Species: Fish, Frogs, and Beyond (Shannon M. Wallace, Jeffrey C. Wolf)....Pages 851-873
Back Matter ....Pages 875-919

✦ Subjects

Biomedicine; Pharmacology/Toxicology; Pathology