Legal regulations for dangerous chemicals are based on estimates of risks. Toxic effects of chemicals vary from one animal species to another. Hence, it is important to know about chemicals' toxicokinetics (uptake, distribution, elimination and metabolism) in animals and about their inter-species di
Toxicokinetics in the evaluation of toxicity data
โ Scribed by Watanabe, P.G.; Schumann, A.M.; Reitz, R.H.
- Book ID
- 121782222
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 498 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0273-2300
No coin nor oath required. For personal study only.
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The toxicology and toxicokinetics of a selegiline transdermal system (STS) were evaluated in a 3 month dog study of daily 24 h applications of placebo 4, 8, or 12 STSs in 32 male and 32 female beagle dogs. Each STS delivered approximately 5 mg selegiline over 24 h. No drug-related signs of toxicity