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Toxicity of the chlordane metabolite oxychlordane in female rats: clinical and histopathological changes

✍ Scribed by Genevieve Bondy; Cheryl Armstrong; Laurie Coady; Josée Doucet; Patrick Robertson; Mark Feeley; Michael Barker

Book ID
117450108
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
679 KB
Volume
41
Category
Article
ISSN
0278-6915

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The effects of cimetidine (CIM) (an inhibitor of the hepatic microsomal monooxygenase system) on the metabolism and hepatotoxicity of trichloroethylene (TRI) were studied in male Sprague-Dawley rats. Rats were given three doses of 120 mg/kg i.p. (low-dose regimen) of CIM at 0, 6 and 11 h for 1 day,