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Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time

โœ Scribed by Hammond, Alison H.; Fry, Jeffrey R.

Book ID
122604081
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
397 KB
Volume
70
Category
Article
ISSN
0378-4274

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Mechanism of toxicity of precocene II in
Mechanism of toxicity of precocene II in rat hepatocyte cultures
โœ Hammond, Alison H. ;Garle, Michael J. ;Fry, Jeffrey R. ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 907 KB

Precocene I1 was more toxic in 24 hour cultures than in 72 hour cultures of rat hepatocytes. In 24 hour cultures, there was no observable toxicity at 75 pM precocene I1 after exposure for 6 hours, but after 24 hours, 65% of the cells were dead. In contrast, although 794 pM killed 50% of the cells in