## Abstract Orthoclone OKT3 is a murine monoclonal antibody that blocks the generation and function of T lymphocytes. It has been shown to be effective in reversing acute cellular rejection in solid organ transplants. However, potential development of antimurine antibodies restricts the duration th
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Toxicity of OKT 3 increases with dosage: a controlled study in renal transplant recipients
โ Scribed by Karine J. Parlevliet; Frederike J. Bemelman; Si-La Yong; C. Erik Hack; Janto Surachno; Joep M. Wilmink; Ineke J. M. Berge; Peter T. A. Schellekens
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 519 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0934-0874
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Renal impairment is common in patients after liver transplantation and is attributable in large part to the use of calcineurin inhibitor (CNI)-based immunosuppression. We sought to determine whether conversion to sirolimus-based immunosuppression was associated with improved renal function. In a sin