Toxicity of litholytic ethylenediaminetetraacetic acid solutions to the urothelium of the rat and dog

✍ Scribed by Oosterlinck, W. ;Verbeeck, R. ;Cuvelier, C. ;Verplaetse, H. ;Verbaeys, A.

• Book ID: 104714916
• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 327 KB
• Volume: 19
• Category: Article
• ISSN: 0300-5623
• DOI: 10.1007/bf00305309

✦ Synopsis

The toxicity to the urothelium of bipotassium ethylene-diaminetetraacetic acid (K2-EDTA) buffered with 0.2 M triethanolamine (TEA) at pH 8 and 8.5 was tested in rats and dogs. Even at a low concentration of 3.125 mM, K2-EDTA is very noxious to the bladder mucosa. This toxicity is not due to the buffer TEA, which is well tolerated. Although buffered K2-EDTA, at pH 8.5 is an excellent chemolytic agent for calcium-containing stones, its clinical use is limited by this toxicity.