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Toxicity of carbon disulfide in developing rats: LD50 values and effects on the hepatic mixed-function oxidase enzyme system

✍ Scribed by E.C. Green; A. Hunter


Book ID
113206561
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
840 KB
Volume
78
Category
Article
ISSN
0041-008X

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A drastic impairment in hepatic mixed-function oxidase (MFO) system was observed in rats 24 h following ip injection of CCl 4 (1.0 ml/kg body weight), as indicated by a decrease in the activities of various microsomal enzymes related to drug metabolism (e.g., aniline hydroxylase, aminopyrine-Ndemeth