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Toxicity of aromatic disulphides. II. Intra-erythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides

✍ Scribed by R. Munday

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 448 KB
Volume: 5
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550050614

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✦ Synopsis

Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro. It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of non-protein and proteinbound thiols) in these cells.

Such changes were also recorded in erythrocytes exposed to 4,4'-diaminodiphenyl disulphide, 2,2'- diaminodiphenyl disulphide, 4,4'-dirnethyldiphenyl disulphide, 4,4'-dinitrodiphenyl disulphide, diphenyl disulphide-2,2'-dicarboxylic acid and dibenzyl disulphide. The relative potency of these coumpounds in causing erythrocyte damage is correlated with their ability to generate 'active oxygen' species in vitro.

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Toxicity of aromatic disulphides. I. Gen

Toxicity of aromatic disulphides. I. Generation of superoxide radical and hydrogen peroxide by aromatic disulphides in vitro

✍ R. Munday 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 679 KB

The aromatic thiol, thiophenol, is readily autoxidized at neutral pH in a reaction which generates superoxide radical and hydrogen peroxide. The oxidation product, diphenyl disulphide, may be reduced back to thiophenol by glutathione and in the presence of an excess of the latter thiol a reduction/a