Toxicity of airborne particulate matter to rat alveolar macrophages: A comparative study of five extracts collected indoors and outdoors

Inhibition of binding of thyroxin to tra

Inhibition of binding of thyroxin to transthyretin by outdoor and indoor airborne particulate matter and effects on thyroid hormone and vitamin A metabolism in rats

✍ G. A. H. Heussen; M. L. J. Hikspoors; A. Spenkelink; A. Brouwer; J. H. Koeman 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 712 KB

Previous studies have indicated that chemicals, e.g., hydroxylated polychlorinated biphenyls (PCBs) decrease plasma thyroxin levels through interaction with transthyretin. As a consequence, plasma vitamin A and thyroxin are depleted. Both thyroxin and vitamin A are important regulators of normal epi