Toxicity of Aflatoxin B1 toHelicoverpa zeaand Bioactivation by Cytochrome P450 Monooxygenases
β Scribed by Ren Sen L. Zeng; Guodong Niu; Zhimou Wen; Mary A. Schuler; May R. Berenbaum
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 900 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0098-0331
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π SIMILAR VOLUMES
We have studied the activation of aflatoxin B, by hamster liver microsomes and purified hamster cytochrome P-450 isozymes using a umu mutagen test. The hamster liver microsomes or S-9 fractions were much more active than rat liver microsomes or s-9 fractions in the activation of umu gene expression
## Abstract The worldwide human exposure to aflatoxin B~1~ (AFB~1~), particularly in developing countries, remains to be a serious public health concern. Although AFB~1~ is best known as a hepatocarcinogen, epidemiological studies have shown a positive association between human lung cancer occurren
## Abstract The relative roles of hepatitis B virus (HBV) and aflatoxn and their possible mechanism of interaction in the etiopathogenesis of hepatocellular carcinoma (HCC) are not understood. One hypothesis is that viral infection and associated liver injury alter expression of carcinogenβmetaboli