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Toxicity of 1,2-dibromoethane in isolated hepatocytes: Role of lipid peroxidation

โœ Scribed by E. Albano; G. Poli; A. Tomasi; A. Bini; V. Vannini; M.U. Dianzani


Book ID
113136753
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
653 KB
Volume
50
Category
Article
ISSN
0009-2797

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tertโ€“butylhydroperoxideโ€”Induced toxicity
โœ Jewell, Sarah A. ;Monte, Donato Di ;Richelmi, Plinio ;Bellomo, Giorgio ;Orrenius ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 514 KB

Incubation of isolated rat hepatocytes with tert-butylhydroperoxide resulted in marked cytotoxicity preceded by intracellular glutathione depletion and extensive lipid peroxidation. Addition of antioxidants delayed, but did not prevent, this toxicity. A significant decrease in protein-free sulfhydr