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Toxicity and dosimetry of 177Lu-DOTA-Y3-octreotate in a rat model

✍ Scribed by Jason S. Lewis; Mu Wang; Richard Laforest; Fan Wang; Jack L. Erion; Joseph E. Bugaj; Ananth Srinivasan; Carolyn J. Anderson

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
84 KB
Volume
94
Category
Article
ISSN
0020-7136

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✦ Synopsis

Radiolabeled somatostatin analogs have demonstrated effectiveness for targeted radiotherapy of somatostatin receptor-positive tumors in both tumor-bearing rodent models and humans. A radionuclide of interest for cancer therapy is reactor-produced 177 Lu (t 1/2 ‫؍‬ 6.64 d; ␤ ؊ [100%]). The high therapeutic efficacy of the somatostatin analog 177 Lu-DOTA-Tyr 3 -octreotate (DOTA-Y3-TATE, where DOTA is 1,4,7,10tetraazacyclododecane-1,4,7,10-tetraacetic acid) was previously demonstrated in a tumor-bearing rat model (Erion et al.,

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