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Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland

✍ Scribed by C Zheng; A Voutetakis; MR Kok; CM Goldsmith; GBJ Smith; S Elmore; A Nyska; M Vallant; RD Irwin; BJ Baum

Book ID: 111271989
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 182 KB
Volume: 12
Category: Article
ISSN: 1354-523X
DOI: 10.1111/j.1601-0825.2005.01170.x

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## Abstract ## Background Radiation‐induced salivary hypofunction is a common side‐effect of treatment for head and neck cancers. Patients suffer significant morbidity and there is no suitable conventional therapy. We are conducting a Phase I clinical trial, using a first‐generation serotype 5 ade