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Toxicities associated with hyperthermic isolated limb perfusion and isolated limb infusion in the treatment of melanoma and sarcoma

✍ Scribed by Möller, Mecker G.; Lewis, James M.; Dessureault, Sophie; Zager, Jonathan S.

Book ID
120520665
Publisher
Informa plc
Year
2008
Tongue
English
Weight
641 KB
Volume
24
Category
Article
ISSN
0265-6736

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Hyperthermic isolated limb perfusion (HILP) with various chemotherapeutic agents has been used for the local treatment of high-grade soft tissue sarcomas (STS) of the extremities, but in most cases, with a disappointing result. Most such regimens certainly should not be considered superior to surger

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Background. Hyperthermic isolated limb perfusion (HILP) has been shown to be effective for locoregional metastases or local recurrent disease. Locoregional recurrences after previous HILP is an unsolved problem. Methods. HILP with cisplatin, 20-30 mg/l perfused limb volume, was performed in seven p