Toxic shock syndrome associated with nasal packing: Analogy to tampon-associated illness: Barbour SD, Shales DM, Guertin SR Pediatrics 73:163–165 Feb 1984
✍ Scribed by Esequiel C Guevara
- Book ID
- 104312956
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 94 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1097-6760
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✦ Synopsis
Acute mountain sickness is characterized by headache, vomiting, insomnia, and lassitude, and occurs when unaccustomed individuals ascend to high altitude. Its etiology is unknown, but theoretically it is due to the development of cerebral edema. Acetazolamide and slow, graduated ascent have been suggested for prevention of symptoms. This study tests the use of dexamethasone in a double-blind, crossover design on eight young volunteers who were exposed to a simulated elevation of 4,570 m (15,000 ft) in an altitude chamber. Dexamethasone (4 mg every 6 h), begun 48 hours before ascent and continued throughout the 42hour exposure, significantly decreased the symptoms of acute mountain sickness as assessed by both questionnaire and clinical interview. The mechanism by which dexamethasone exerted its beneficial action is unknown.