✦ LIBER ✦

Toxic hydrolysis product from a biodegradable foam implant

✍ Scribed by Batich, Chris ;Williams, Jerry ;King, Roy

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 464 KB
Volume: 23
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820231406

No coin nor oath required. For personal study only.

✦ Synopsis

A commercially available mammary implant containing a soft polyester polyurethane foam shell has been examined for possible diamine hydrolysis products. Fourier Transform Infrared (FT-IR) analysis has shown ester and aromatic structures present in the intact foam shell. Vigorous hydrolysis conditions using NaOH have produced a mixture with large amounts of toluene diamine (TDA) present as determined by Gas Chromatography-Mass Spectrometry (GC/MS), and GC/FT-IR. There are numerous clinical reports of the degradation of this implant shell after implantation with incorporation of fragments into phagocytic cells at the implantation site. Recent reports have discussed late pain and other allergic reactions to this implant. Release of the known toxic material, TDA, is consistent with these observations and strongly suggests that an alternative material be used in this application.

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