Toxic epidermal necrolysis in acquired immunodeficiency syndrome treated with intravenous gammaglobulin

✍ Scribed by Tri G Phan; Richard Cw Wong; Kerry Crotty; Stephen Adelstein

• Book ID: 104468941
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 300 KB
• Volume: 40
• Category: Article
• ISSN: 0004-8380
• DOI: 10.1046/j.1440-0960.1999.00347.x

✦ Synopsis

A 31‐year‐old man with the acquired immunodeficiency syndrome who developed toxic epidermal necrolysis (TEN) was successfully treated with intravenous immunoglobulin. He presented with a widespread, blistering skin rash, extensive mucosal ulceration, high‐grade fever and pancytopaenia. Nevirapine, a non‐nucleoside reverse transcriptase inhibitor, was suspected as the culprit drug, although the patient had been taking this medication for 6 months. The patient also demonstrated an increased number of gamma/delta (γδ) T cells that decreased concomitantly with his clinical improvement. This correlation has not been described in TEN previously and may be of pathophysiological significance.