Toxic effect of valproic acid on tryptophan binding to rat hepatic nuclei
β Scribed by Herschel Sidransky; Ethel Verney
- Book ID
- 107939052
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 962 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0300-483X
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π SIMILAR VOLUMES
## Abstract A multiβage rat model was evaluated as a means to identify a potential ageβrelated difference in liver injury following exposure to valproic acid (VPA), a known pediatric hepatotoxic agent. Different age groups of SpragueβDawley (SD) rats (10β, 25β, 40β, 80βdayβold) were administered VP
Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1