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Toxic dermatitis induced by 10-ethyl-10-deazaaminopterin (10-EdAM), a novel antifolate

โœ Scribed by Jaap Verweij; Jan Schornagel; Pieter De Mulder; Sonja Henzen-Logmans; Francesco Cognetti; Michel Clavel; Jan Vermorken

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
444 KB
Volume
66
Category
Article
ISSN
0008-543X

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lo-ethyl-1 0-deazaaminopterin (1 0-EDAM) is a rationally designed derivative of the antifolate. methotrexate (MTX). In a number of tumor models these design features have resulted in an improved spectrum of antiproliferative activity as compared with the parent compound. Using an MTT growth assay, w