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Towards β-globin gene-targeting with integrase-defective lentiviral vectors

✍ Scribed by Davoud Nouri Inanlou; Bagher Yakhchali; Hossein Khanahmad; Mossa Gardaneh; Hesam Movassagh; Reza Ahangari Cohan; Mehdi Shafiee Ardestani; Reza Mahdian; Sirous Zeinali

Book ID
106364850
Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
343 KB
Volume
32
Category
Article
ISSN
0141-5492

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## Abstract Lentiviral vectors efficiently integrate into the host genome of both dividing and nondividing cells, and so they have been used for stable transgene expression in biological and biomedical studies. However, recent studies have highlighted the risk of insertional mutagenesis and subsequ