Towards the treatment of Alzheimer's disease: Discovery and development of novel subtype-specific M1 allosteric agonists
β Scribed by Lebois, Evan P.; Bridges, Thomas M.; Dawson, Eric S.; Kennedy, J. Phillip; Xiang, Zixiu; Jadhav, Satyawan B.; Yin, Huiyong; Meiler, Jens; Jones, Carrie K.; Conn, P. Jeffrey; Weaver, C. David; Lindsley, Craig W.
- Book ID
- 123252006
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 41 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1552-5260
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Clinical trials in Alzheimer's disease (AD) with first generation muscarinic agonists (e.g., arecoline, oxotremorine, pilocarpine) produced inconsistent results due to poor pharmacokinetic properties and a lack of separation between central and peripheral activities observed with these compounds. Se