Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes

✍ Scribed by Mark Woods; Zoltan Kovacs; Shanrong Zhang; A. Dean Sherry

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 124 KB
• Volume: 42
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200352234

✦ Synopsis

The high spin state and long electronic relaxation time of the gadolinium(iii) ion renders it an ideal basis for contrast media for use in magnetic resonance imaging (MRI). The throughspace dipole-dipole interactions by which the unpaired f electrons of gadolinium catalyze the relaxation of proximate water-molecule protons are strongly distance dependent. For this reason, the protons of water molecules coordinated to gadolinium are the most effectively relaxed. Exchange of