✦ LIBER ✦
Towards polyketide libraries — II: Synthesis of chiral aracemic di- and triketides on a solid support
✍ Scribed by Michael Reggelin; Volker Brenig; Reinhard Welcker
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 216 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A new fluoride ion cleavable linker serves as starter unit for iterative asymmetric aldol reactions on a solid support. The synthetic protocol relies on the boron enolate chemistry of D. A. Evans and a cyclic reestablishment of key functionalities. It entails the opportunity for the generation ofdi-and triketide libraries.