𝔖 Bobbio Scriptorium
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Towards optimal design of anti-malarial pharmacokinetic studies

✍ Scribed by Julie A Simpson, Kris M Jamsen, Ric N Price, Nicholas J White…


Book ID
120686923
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
211 KB
Volume
8
Category
Article
ISSN
1475-2875

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The disposition of three 4-aminoquinoline leads, namely isoquine (ISO), des-ethyl isoquine (DEI) and N-tert-butyl isoquine (NTBI), were studied in a range of in vivo and in vitro assays to assist in selecting an appropriate candidate for further development. Analogous to amodiaquine (ADQ), ISO under