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Towards oncological application of Raman spectroscopy

✍ Scribed by Annieke Nijssen; Senada Koljenović; Tom C. Bakker Schut; Peter J. Caspers; Gerwin J. Puppels

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
251 KB
Volume
2
Category
Article
ISSN
1864-063X

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✦ Synopsis

Abstract

As the possibilities in the treatment of cancer continue to evolve, its early detection and correct diagnosis are becoming increasingly important. From the early detection of cancer to the guidance of oncosurgical procedures new sensitive in vivo diagnostic tools are much needed. Many studies report the Raman spectroscopic detection of malignant and premalignant tissues in different sites of the body with high sensitivities. The great appeal of this technique lies in its potential for in vivo clinical implementation. We present an overview of the in vitro and in vivo work on the oncological application of Raman spectroscopy and discuss its potential as a new tool in the clinico‐oncological practice. Opportunities for integration of Raman spectroscopy in oncological cure and care as a real‐time guidance tool during diagnostic (i.e. biopsy) and therapeutic (surgical resection) modalities as well as technical shortcomings are discussed from a clinician's point of view. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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