Towards cracking the epigenetic code using a combination of high-throughput epigenomics and quantitative mass spectrometry-based proteomics
✍ Scribed by Hendrik G. Stunnenberg; Michiel Vermeulen
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 153 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
High‐throughput genomic sequencing and quantitative mass spectrometry (MS)‐based proteomics technology have recently emerged as powerful tools, increasing our understanding of chromatin structure and function. Both of these approaches require substantial investments and expertise in terms of instrumentation, experimental methodology, bioinformatics, and data interpretation and are, therefore, usually applied independently from each other by dedicated research groups. However, when applied reiteratively in the context of epigenetics research these approaches are strongly synergistic in nature.