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Towards accurate in vivo spectroscopy of the human prostate

✍ Scribed by Tomas Svensson; Erik Alerstam; Margrét Einarsdóttír; Katarina Svanberg; Stefan Andersson-Engels

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
194 KB
Volume
1
Category
Article
ISSN
1864-063X

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✦ Synopsis

Abstract

The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time‐of‐flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in the human prostate. For the first time, we demonstrate Monte Carlo‐based evaluation of in vivo TOF photon migration data. We show that this approach is crucial in order to avoid the large errors associated with the use of time‐resolved diffusion theory of light propagation in prostate‐like tissues. This progress also allows us to present the first in vivo scattering spectroscopy of human prostate tissue. Furthermore, TOF spectroscopy, in contrast to the more common steady‐state approach, is insensitive to bleedings, and has been found highly reliable (100% success rate). (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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