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Towards a rational design of resolving agents. Part III. structural study of two pairs of diastereomeric salts of ephedrine and a cyclic phosphoric acid

✍ Scribed by F. J. J. Leusen; H. J. Bruins Slot; J. H. Noordik; A. D. van der Haest; H. Wynberg; A. Bruggink

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
450 KB
Volume
110
Category
Article
ISSN
0165-0513

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Towards a rational design of resolving a
Towards a rational design of resolving agents. Part IV. Crystal packing analyses and molecular mechanics calculations for five pairs of diastereomeric salts of ephedrine and a cyclic phosphoric acid
✍ Frank J. J. Leusen; Hubert J. Bruins Slot; Jan H. Noordik; Albertus D. van der H 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 696 KB

## Abstract Detailed structural studies of five pairs of diastereomeric salts of ephedrine and halogen‐substituted chiral cyclic phosphoric acids indicate a correlation between the efficiency of the resolution process and the lattice energy difference between the salts of a diastereomeric pair. Att

Towards a rational design for resolving
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## Abstract The effects of various aromatic substituents in both ephedrine and a cyclic phosphoric acid on the quality of resolution via diastereomeric salt formation are investigated. The diastereo‐selective synthesis of a novel series of chloro‐substituted ephedrines is described. These chloroeph

Towards a rational design of resolving a
Towards a rational design of resolving agents. Part II: Correlation between resolution results and physical properties of diastereomeric salts
✍ A. D. van der Haest; H. Wynberg; F. J. J. Leusen; A. Bruggink 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 525 KB

## Abstract Six closely related cyclic phosphoric acids (1a‐f) were compared with respect to their resolving ability towards ephedrine. Variation of the aromatic substituent in the phosphoric acids significantly influences this ability. Studying the results of the resolution experiments as a functi