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Towards a Quantitative Model of Immunogenicity: Counting Pathways in Sequence Space

โœ Scribed by TYLIS Y CHANG

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
651 KB
Volume
206
Category
Article
ISSN
0022-5193

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โœฆ Synopsis

One of the fundamental aims of structural biology is the identi"cation of high-a$nity ligands for arbitrary receptors. The maturation of the antibody repertoire elegantly and robustly solves this problem through an evolutionary mechanism comprising repeated cycles of mutation and preferential replication. To understand better the limitations and biases of this process, we developed an interpretation of antibody maturation within the framework of sequence space and "tness landscapes. Several well-described phenomena can be directly derived from this framework, and new predictions can be made. Ultimately, this reconceptualization of the clonal selection process suggests a quantitative, testable model of immunogenicity.

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