We review the data from studies of mouse mutants that lend insight to the mechanisms that lead to neural tube defects (NTDs). Most of the 50 single-gene mutations that cause neural tube defects (NTDs) in mice also cause severe embryonic-lethal syndromes, in which exencephaly is a nonspecific feature
Toward understanding the genetic basis of neural tube defects
โ Scribed by Z Kibar; V Capra; P Gros
- Book ID
- 110888389
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 424 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0009-9163
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Neural tube defects are a complex, heterogeneous, and multifactorial group of disorders. In humans it is estimated that 80% of neural tube defects are ''multifactorial'' and are influenced by both genetic and environmental factors. It appears that 70% of neural tube defects in humans are related to
## Abstract The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds 240, including 205 representing specific genes, 30 for unidentified genes, and 9 multifactorial strains. These mutants identify genes needed for embryonic neural tube closure. Reports of 50 new NTD mutan