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Toward the development of criteria for global flares in juvenile systemic lupus erythematosus

✍ Scribed by Hermine I. Brunner; Marisa S. Klein-Gitelman; Gloria C. Higgins; Sivia K. Lapidus; Deborah M. Levy; Anne Eberhard; Nora Singer; Judyann C. Olson; Karen Onel; Marilynn Punaro; Laura Schanberg; Emily von Scheven; Jun Ying; Edward H. Giannini

Publisher
Wiley (John Wiley & Sons)
Year
2010
Tongue
English
Weight
258 KB
Volume
62
Category
Article
ISSN
2151-464X

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## Abstract ## Objective Accumulation of apoptotic cells may lead to the development of systemic lupus erythematosus (SLE) through a breakdown in immune tolerance. Altered neutrophil apoptosis may contribute to nuclear autoantigen exposure, ultimately leading to autoantibody generation. This study