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Toward a Structure−Activity Relationship for Apoptolidin: Selective Functionalization of the Hydroxyl Group Array

✍ Scribed by Wender, Paul A.; Jankowski, Orion D.; Tabet, Elie A.; Seto, Haruo


Book ID
115499102
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
81 KB
Volume
5
Category
Article
ISSN
1523-7060

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Evidence for a Structure-Function Relati
✍ Bruce L Martin 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 181 KB

Kinetic parameters for the metal ion activation of calcineurin at 30°C were found to be correlated to the formation constants (log K 1 ) of the activating metal ions (Mn 2+ , Co 2+ , Ni 2+ , Zn 2+ , and Mg 2+ ) with the substrate para-nitrophenyl phosphate (pNPP). Metal ion activation measured by k