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Toward a Rational Design of Peptide Inhibitors of Ribonucleotide Reductase: Structure−Function and Modeling Studies

✍ Scribed by Pender, Bari A.; Wu, Xu; Axelsen, Paul H.; Cooperman, Barry S.

Book ID
126965766
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
431 KB
Volume
44
Category
Article
ISSN
0022-2623

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## Abstract This study presents an approach that can be used to search for lead peptide candidates, including unconstrained structures in a recognized sequence. This approach was performed using the design of a competitive inhibitor for 3‐hydroxy‐3‐methylglutaryl CoA reductase (HMGR). In a previous