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Tow-Carbon Homologation of Ketones via Sily Ketene Acetals: Synthesis of α,β-Unsaturated Acids and α-Trimethylsilyl δ-Ketoacids.

✍ Scribed by Moncef Bellassoued; Sinda Mouelhi; Pierre Fromentin; Aurelien Gonzalez


Publisher
John Wiley and Sons
Year
2005
Weight
36 KB
Volume
36
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Stereoselective synthesis of (E)- α, β -
✍ Moncef Bellassoued; Marcel Gaudemar 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 169 KB

Aldehydes are converted into (E)-CI , fi -unsaturated carboxylic acids by means of C,O,O -tri(trimethylsilyl) ketene acetal and a catalytic amount of ZnBr2. Several ways have been described to transform aldehydes into c1 , 6 -unsaturated esters. However, the hydrolysis of the resultant esters to t