Totally diastereoselective synthesis of a new chiral quinoline diazaphospholidine ligand and its derivatives

✍ Scribed by Guillaume Delapierre; Mathieu Achard; Gérard Buono

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 108 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00691-3

✦ Synopsis

QUIPHOS-PN5, a new stable P,N ligand with a stereogenic phosphorus centre was synthesised in two steps from 8-bromoquinoline (61% yield). Its structure and its bidentate chelating ability was confirmed by the X-ray structure of a palladium(II) complex with this ligand. P(V) derivatives of QUIPHOS-PN5 were then easily obtained in excellent yields (85-100%).