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Total Synthesis of Zaragozic Acid A/Squalestatin S1

✍ Scribed by Prof. Dr. Kyriacos C. Nicolaou; Alan Nadin; James E. Leresche; Eddy W. Yue; Susan La Greca


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
264 KB
Volume
33
Category
Article
ISSN
0044-8249

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## Abstract The pseudo __C__~2~‐symmetrical diketone **22** was efficiently constructed from furan‐3,4‐dimethanol (**7**) using a two‐directional route featuring a double asymmetric dihydroxylation. Acidic hydrolysis of the cyclopentylidene acetals of **22** triggered a selective cyclization of the