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Total Synthesis of the Polyene Macrolide Roflamycoin

✍ Scribed by Rychnovsky, Scott D.; Khire, Uday R.; Yang, Guang


Book ID
126069948
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
219 KB
Volume
119
Category
Article
ISSN
0002-7863

No coin nor oath required. For personal study only.


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Es route to polyene macrolide total synt
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Four sections of Roflamycoin. labeled A, 1. Q, and E, which correspond to 10 of the 11 chiral centers in this natural product, have been prepared. The polyene macrolides, by virtue of their potent antifungal properties, constitute an important class of clinically valuable natural products.2 Most of

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