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Total synthesis of the macrolide (+)-aspicilin by an asymmetrically catalyzed macrocyclization of an ω-Alkynal ester

✍ Scribed by Wolfgang Oppolzer; Rumen N Radinov; Jef De Brabander


Book ID
103404982
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
206 KB
Volume
36
Category
Article
ISSN
0040-4039

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✍ Ze Tan; Ei-ichi Negishi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 1 views

We recently reported an efficient and general method for the synthesis of reduced polypropionates with a single heterofunction [1] through the application of Zr-catalyzed asymmetric carboalumination. [2, 3] In view of the large number of complex natural products that are of medicinal and biological