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Total Synthesis of the Boron-Containing Ion Carrier Antibiotic Macrodiolide Tartrolon B (I).

✍ Scribed by Johann Mulzer; Markus Berger

Publisher
John Wiley and Sons
Year
2004
Weight
62 KB
Volume
35
Category
Article
ISSN
0931-7597

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An efficient synthesis of the protected seco acid 2 of the antibiotic macrodiolide tartrolon 1 is described. Key steps are a substrate controlled aldol-reaction, a Johnson-Claisen rearrangement, and a Horner-Wadsworth-Emmons olefination with subsequent Corey-Bakshi-Shibata (CBS) reduction.