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Total synthesis of the anti-inflammatory lipid mediator Resolvin E2

โœ Scribed by Ana R. Rodriguez; Bernd W. Spur


Book ID
113930585
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
199 KB
Volume
53
Category
Article
ISSN
0040-4039

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Total synthesis of resolvin E2
โœ Yusuke Kosaki; Narihito Ogawa; Yuichi Kobayashi ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 589 KB

Resolvin E2 (2) was synthesized stereoselectively using the C1-8 and C15-20 aldehydes 6 and 9, which were connected to the C9-14 fragment by using Wittig reactions. The aldehyde 6 was prepared from the c-silyl alcohol (S)-20 by a sequence of reactions involving ozonolysis, oxidation with NaIO 4 , an