Total synthesis of ring-c aromatic 18-nor steroid
β Scribed by A. Chatterjee; B.G. Hazra
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 814 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
A new strategy for introducing an hydroxy group at the position 3 of an aromatic A ring in a steroid, which is a key position for biological purposes, is described. This procedure has required a judicious choice of a t-butyl ether as protective group at the beginning of the synthesis, and its deprot
## Abstract Cationic cyclization of 2β[6β(3βmethoxyphenyl)β(Z)β3βhexenyl]β3βmethylβ2βcyclopentenol (7a) produced 1β and 3βmethoxyβ17βmethylβ8Ξ±βgonaβ1,3,5(10),13(17)βtetraene (**8a** and **9a**) with complete stereospecificity. Cyclization of similar substrates with an alkyl substituent in the appro