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Total Synthesis of rac-γ-Indomycinone by Baker–Venkataraman Rearrangement

✍ Scribed by Karsten Krohn; Hoan Trang Tran-Thien; Jürgen Vitz; Anne Vidal


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
161 KB
Volume
2007
Category
Article
ISSN
1434-193X

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General Approach to Anthrapyran Antibiot
✍ Karsten Krohn; Hoan Trang Tran-Thien; Ishtiaq Ahmed 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB

## Abstract A new general route to the anthrapyran antibiotics is presented, which allows the attachment of various branched side chains. A key step is the Baker–Venkataraman rearrangement of the propionate **9** to the diketone **10**. Acid‐catalyzed cyclization gives the ethyl‐branched anthrapyra