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Total synthesis of penmacric acids via an intermolecular radical addition reaction

✍ Scribed by Ueda, Masafumi; Ono, Ayako; Nakao, Dai; Matsuno, Kenji; Naito, Takeaki; Miyata, Okiko


Book ID
120470285
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
814 KB
Volume
69
Category
Article
ISSN
0040-4020

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The phytotoxin herbarumin I, isolated from Phoma herbarum, was stereoselectively synthesized in 17 steps and 6% yield from L-arabinose featuring the intermolecular Nozaki-Hiyama-Kishi coupling and modified Yamaguchi macrolactonization as key steps.