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Total synthesis of new 1,5-bissubstituted myo-inositol derivatives. Synthesis of D-myo-inositol 1,5-bisphosphate, 3,5-bisphosphate and of rac. 1,5-Bissulphated and 1,5-bissulphamoylated isosteric analogues

✍ Scribed by Pieter Westerduin; Henrica A.M. Willems; Constant A.A. van Boeckel


Book ID
104228499
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
209 KB
Volume
31
Category
Article
ISSN
0040-4039

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Synthesis of (Β±)-myo-inositol 1,4,5-tris
✍ Nicholas J. Noble; Allan M. Cooke; Barry V.L. Potter πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 758 KB

Novel routes to myo-inositol 1,4,5trisphosphate and a phosphorothioate analogue involving mixed P(V) and P(III) chemistry have been developed. Phosphorylation of 2,3,6-tri-O-benzyl-myo-inositol l-[di-(2,2,2-trichloroethyl) phosphate] with bis(2,2,2-trichloroethyl) phosphorochloridate gave a mixture